APOE and APOC1 genetic polymorphisms in age-associated memory impairment

被引：0
|
作者：
Bartrés-Faz, D
Clemente, IC
Junqué, C
Valveny, N
López-Alomar, A
Sánchez-Aldeguer, J
López-Guillén, A
Moral, P
机构：
[1] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona 08036, Spain
[2] Univ Barcelona, Anthropol Unit, Dept Biol Anim, Barcelona, Spain
[3] Autonomous Univ Barcelona, EU Gimbernat, Barcelona, Spain
[4] Catalonian Inst Hlth, CAP, Barcelona, Spain
来源：
NEUROGENETICS | 2001年 / 3卷 / 04期
关键词：
apolipoproteins; genetic; memory; impairment; aging;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We studied the distribution of two genetic polymorphisms (APOE and APOC1) in a sample of 100 subjects fulfilling the NIMH criteria for age-associated memory impairment (AAMI) and 124 controls. We found significant associations both for APOE and APOC1 loci and their combinations with the AAMI condition. The findings in our sample suggest that memory-impaired subjects as described by the NIMH may be genetically differentiated from normally aging subjects in relation to these two polymorphisms and indicate the interest of considering variations in the APOC1 gene for further studies in cognitive aging.
引用
收藏
页码：215 / 219
页数：5
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