Solid-phase synthesis of thrombin inhibitors

被引：14

作者：

Lange, UEW ^{[1
]}

Zechel, C ^{[1
]}

机构：

[1] BASF AG, D-67056 Ludwigshafen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00251-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A newly developed convergent solid-phase synthesis provides efficient access to thrombin inhibitors of the D-Phe-Pro-Arg type. Members of the synthesized libraries inhibited thrombin with IC(50)s in the nanomolar range. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1571 / 1573

页数：3

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