Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II)

被引：2
|
作者：
Na, Yu-Ran [1 ,2 ]
Woo, Dustin J. [1 ,3 ]
Choo, Hyunah [3 ,4 ]
Chung, Hak Suk [1 ,3 ]
Yang, Eun Gyeong [1 ,3 ]
机构：
[1] Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul 136791, South Korea
[2] Korea Univ, Res Inst Nat Sci, Dept Chem, Seoul 136701, South Korea
[3] Korea Univ Sci & Technol UST, Dept Biol Chem, Seoul 136791, South Korea
[4] Korea Inst Sci & Technol, Ctr Neuromed, Brain Sci Inst, Seoul 136791, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 53期
关键词：
ERYTHROPOIETIN GENE; HIF-ALPHA; FACTOR-I; BINDING; DESFERRIOXAMINE; COPPER;
D O I：
10.1039/c5cc02143j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein that Zn(II) selectively inhibits the hypoxia- inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.
引用
收藏
页码：10730 / 10733
页数：4
相关论文
共 50 条
  • [21] Hypoxia-inducible factor prolyl hydroxylase inhibitors in kidney transplant recipients
    Ogata, Masatomo
    Miyauchi, Takamasa
    Sakurai, Yuko
    Murata, Marie
    Shinoda, Kazunobu
    Shibagaki, Yugo
    Yazawa, Masahiko
    CLINICAL KIDNEY JOURNAL, 2022, 15 (05) : 1024 - 1026
  • [22] FDA approves first hypoxia-inducible factor prolyl hydroxylase inhibitor
    Mullard, Asher
    NATURE REVIEWS DRUG DISCOVERY, 2023, 22 (03) : 173 - 173
  • [23] Selective inhibition of factor inhibiting hypoxia-inducible factor
    McDonough, MA
    McNeill, LA
    Tilliet, M
    Papamicaël, CA
    Chen, QY
    Banerji, B
    Hewitson, KS
    Schofield, CJ
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (21) : 7680 - 7681
  • [24] Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition Attenuates Chronic Stress Induced Intestinal Barrier Dysfunction
    Luo, Beibei
    Xiang, Dao
    Chen, Peijie
    Nieman, David C.
    Liu, Yu
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2015, 47 (05): : 603 - 604
  • [25] Hypoxia-inducible factor prolyl 4-hydroxylase inhibition - A target for neuroprotection in the central nervous system
    Siddiq, A
    Ayoub, IA
    Chavez, JC
    Aminova, L
    Shah, S
    LaManna, JC
    Patton, SM
    Connor, JR
    Cherny, RA
    Volitakis, I
    Bush, AI
    Langsetmo, I
    Seeley, T
    Gunzler, V
    Ratan, RR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (50) : 41732 - 41743
  • [26] Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis
    Rahtu-Korpela, Lea
    Maatta, Jenni
    Dimova, Elitsa Y.
    Horkko, Sohvi
    Gylling, Helena
    Walkinshaw, Gail
    Hakkola, Jukka
    Kivirikko, Kari I.
    Myllyharju, Johanna
    Serpi, Raisa
    Koivunen, Peppi
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (04) : 608 - 617
  • [27] Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen
    Flashman, Emily
    Hoffart, Lee M.
    Hamed, Refaat B.
    Bollinger, J. Martin, Jr.
    Krebs, Carsten
    Schofield, Christopher J.
    FEBS JOURNAL, 2010, 277 (19) : 4089 - 4099
  • [28] ROXADUSTAT Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor Treatment of Anemia
    Virgili-Lopez, G.
    DRUGS OF THE FUTURE, 2014, 39 (11) : 783 - 791
  • [29] Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates
    Wang, L.
    Cui, S.
    Ma, L.
    Kong, L.
    Geng, X.
    INSECT MOLECULAR BIOLOGY, 2015, 24 (06) : 634 - 648
  • [30] Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light
    Li, Zhihong
    Su, Kaijun
    Jiang, Zhensheng
    Yu, Yancheng
    You, Qidong
    Zhang, Xiaojin
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (16) : 7583 - 7588
12345