ORAL C5A RECEPTOR ANTAGONIST CCX168 IN A PHASE 2 CLINICAL TRIAL IN ANCA-ASSOCIATED RENAL VASCULITIS

被引:0
|
作者
Bekker, Pirow [1 ]
Potarca, Antonia [1 ]
Dairaghi, Daniel [1 ]
Miao, Shichang [1 ]
Powers, Jay P. [1 ]
Jaen, Juan C. [1 ]
Schall, Thomas J. [1 ]
机构
[1] Chemocentryx Inc, Mountain View, CA USA
关键词
D O I
暂无
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
引用
收藏
页码:419 / 420
页数:2
相关论文
共 41 条
  • [21] Avacopan C5a anaphylatoxin chemotactic receptor 1 (C5aR1) antagonist, Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
    Pease, J. E.
    DRUGS OF THE FUTURE, 2021, 46 (03) : 183 - 190
  • [22] Avacopan, a Novel Competitive C5a Receptor Antagonist, for Severe Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
    Ivan D. Nguyen
    Evan S. Sinnathamby
    Joseph Mason
    Bretton Urban
    Elisa E. Neuchat
    Danielle M. Wenger
    Shahab Ahmadzadeh
    Sahar Shekoohi
    Alan D. Kaye
    Clinical Drug Investigation, 2023, 43 : 595 - 603
  • [23] Avacopan, a Novel Competitive C5a Receptor Antagonist, for Severe Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
    Nguyen, Ivan D.
    Sinnathamby, Evan S.
    Mason, Joseph
    Urban, Bretton
    Neuchat, Elisa E.
    Wenger, Danielle M.
    Ahmadzadeh, Shahab
    Shekoohi, Sahar
    Kaye, Alan D.
    CLINICAL DRUG INVESTIGATION, 2023, 43 (08) : 595 - 603
  • [24] Avacopan, a selective C5a receptor antagonist, for anti-neutrophil cytoplasmic antibody-associated vasculitis
    Harigai, Masayoshi
    Takada, Hideto
    MODERN RHEUMATOLOGY, 2022, 32 (03) : 475 - 483
  • [25] Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study
    Bekker, Pirow
    Dairaghi, Daniel
    Seitz, Lisa
    Leleti, Manmohan
    Wang, Yu
    Ertl, Linda
    Baumgart, Trageen
    Shugarts, Sarah
    Lohr, Lisa
    Dang, Ton
    Miao, Shichang
    Zeng, Yibin
    Fan, Pingchen
    Zhang, Penglie
    Johnson, Daniel
    Powers, Jay
    Jaen, Juan
    Charo, Israel
    Schall, Thomas J.
    PLOS ONE, 2016, 11 (10):
  • [26] Safety and Efficacy of Oral Chemokine Receptor 1 Antagonist CCX354-C in a Phase 2 Rheumatoid Arthritis Study
    Tak, Paul P.
    Balanescu, Andra
    Tseluyko, Vira
    Bojin, Silvia
    Drescher, Edit
    Dairaghi, Dan
    Miao, Shichang
    Marchesin, Vittorio
    Jaen, Juan
    Bekker, Pirow
    Schall, Thomas J.
    ARTHRITIS AND RHEUMATISM, 2011, 63 (12): : 4046 - 4046
  • [27] Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
    Merkel, Peter A.
    Niles, John
    Jimenez, Richard
    Spiera, Robert F.
    Rovin, Brad H.
    Bomback, Andrew
    Pagnoux, Christian
    Potarca, Antonia
    Schall, Thomas J.
    Bekker, Pirow
    ACR OPEN RHEUMATOLOGY, 2020, 2 (11) : 662 - 671
  • [28] A Randomized, Double-Blind, Phase II Study of Glucocorticoid Replacement by Vilobelimab, an Anti-C5a Monoclonal Antibody, in ANCA-Associated Vasculitis
    Merkel, Peter
    Hellmich, Bernhard
    Pfaff, Anja
    Muller, Carina
    Startseva, Elena
    Jayne, David
    ARTHRITIS & RHEUMATOLOGY, 2022, 74 : 1054 - 1055
  • [29] Remission, Glucocorticoid Toxicity, Health-Related Quality of Life, and Safety Outcomes in Patients with Renal Involvement in the Phase 3 Trial of Avacopan for the Treatment of ANCA-Associated Vasculitis
    Geetha, Duvuru
    Cortazar, Frank
    Bruchfeld, Annette
    Karras, Alexandre
    Merkel, Peter
    Jayne, David
    ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 1363 - 1364
  • [30] Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study (vol 11, e0164646, 2016)
    Bekker, Pirow
    Dairaghi, Daniel
    Seitz, Lisa
    Leleti, Manmohan
    Wang, Yu
    Ertl, Linda
    Baumgart, Trageen
    Shugarts, Sarah
    Lohr, Lisa
    Dang, Ton
    Miao, Shichang
    Zeng, Yibin
    Fan, Pingchen
    Zhang, Penglie
    Johnson, Daniel
    Powers, Jay
    Jaen, Juan
    Charo, Israel
    Schall, Thomas J.
    PLOS ONE, 2019, 14 (01):