Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer

被引：17

作者：

Ishikawa, Takeshi ^{[1
]}

Kokura, Satoshi ^{[1
]}

Sakamoto, Naoyuki ^{[2
]}

Okajima, Manabu ^{[1
]}

Matsuyama, Tatsuzo ^{[1
]}

Sakai, Hiromi ^{[1
]}

Okumura, Yoko ^{[1
]}

Adachi, Satoko ^{[1
]}

Yoshida, Naohisa ^{[1
]}

Uchiyama, Kazuhiko ^{[1
]}

Handa, Osamu ^{[1
]}

Takagi, Tomohisa ^{[1
]}

Konishi, Hideyuki ^{[1
]}

Wakabayashi, Naoki ^{[1
]}

Yagi, Nobuaki ^{[1
]}

Ando, Takashi ^{[1
]}

Uno, Kazuko ^{[3
]}

Naito, Yuji ^{[1
]}

Yoshikawa, Toshikazu ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Gastroenterol & Hepatol, Kyoto 6038151, Japan

[2] Iseikai Hyakumanben Clin, Kyoto, Japan

[3] Louis Pasteur Ctr Med Res, Kyoto, Japan

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 03期

关键词：

Quality of life; Cytokines; Cancer; Interleukin-6; Vascular endothelial growth factor; INDUCED SICKNESS BEHAVIOR; ENDOTHELIAL GROWTH-FACTOR; TO-BRAIN COMMUNICATION; EUROPEAN-ORGANIZATION; PSYCHOSOCIAL FACTORS; INTERLEUKIN-6; CARCINOMA; MECHANISMS; FATIGUE; DISEASE;

D O I：

10.1016/j.clinbiochem.2011.09.007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique. Design and methods: 50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels. Results: Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (beta=-0.238, P=0.0126) and cognitive functioning (beta=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (beta=-0.414, P=0.039). Conclusion: This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：207 / 211

页数：5

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