Expression of Calcineurin Activity after Lung Transplantation: A 2-Year Follow-Up

被引：15
|
作者：
Sanquer, Sylvia [1 ,2 ,3 ]
Amrein, Catherine [4 ]
Grenet, Dominique [5 ]
Guillemain, Romain [4 ]
Philippe, Bruno [5 ]
Boussaud, Veronique [4 ]
Herry, Laurence [1 ,2 ,3 ]
Lena, Celine [1 ,2 ,3 ]
Diouf, Alphonsine [1 ,2 ,3 ]
Paunet, Michelle [6 ]
Billaud, Eliane M. [7 ,8 ]
Loriaux, Francoise [9 ]
Jais, Jean-Philippe [8 ,10 ]
Barouki, Robert [1 ,2 ,3 ]
Stern, Marc [5 ]
机构：
[1] Hop Univ Necker Enfants Malad, AP HP, Serv Biochim Metabol & Prote, Paris, France
[2] INSERM, UMR S 747, Paris, France
[3] Univ Paris 05, Ctr Univ St Peres, Paris, France
[4] Hop Europeen Georges Pompidou, AP HP, Serv Chirurg Cardiovasc, Paris, France
[5] Hop Foch, Serv Pneumol, Paris, France
[6] Hop Foch, Biol Lab, Suresnes, France
[7] Hop Europeen Georges Pompidou, AP HP, Serv Pharmacol, Paris, France
[8] Univ Paris 05, Paris, France
[9] Hop Europeen Georges Pompidou, AP HP, Serv Biochim, Paris, France
[10] Hop Necker Enfants Malad, AP HP, Serv Biostat, Paris, France
来源：
PLOS ONE | 2013年 / 8卷 / 03期
关键词：
BRONCHIOLITIS-OBLITERANS-SYNDROME; ALLOGRAFT-REJECTION; BLOOD-CONCENTRATION; RISK-FACTORS; RECIPIENTS; CYCLOSPORINE; IMMUNOSUPPRESSION; CA2+/CALCINEURIN; ACTIVATION; TACROLIMUS;
D O I：
10.1371/journal.pone.0059634
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The objective of this pharmacodynamic study was to longitudinally assess the activity of calcineurin during the first 2 years after lung transplantation. From March 2004 to October 2008, 107 patients were prospectively enrolled and their follow-up was performed until 2009. Calcineurin activity was measured in peripheral blood mononuclear cells. We report that calcineurin activity was linked to both acute and chronic rejection. An optimal activity for calcineurin with two thresholds was defined, and we found that the risk of rejection was higher when the enzyme activity was above the upper threshold of 102 pmol/mg/min or below the lower threshold of 12 pmol/mg/min. In addition, we report that the occurrence of malignancies and viral infections was significantly higher in patients displaying very low levels of calcineurin activity. Taken together, these findings suggest that the measurement of calcineurin activity may provide useful information for the management of the prevention therapy of patients receiving lung transplantation.
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页数：9
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