Sortase A-Inhibitory Metabolites from a Marine-Derived Fungus Aspergillus sp.

被引：11
|
作者：
Park, Sung Chul [1 ]
Chung, Beomkoo [2 ]
Lee, Jayho [2 ]
Cho, Eunji [2 ]
Hwang, Ji-Yeon [1 ]
Oh, Dong-Chan [1 ]
Shin, Jongheon [1 ]
Oh, Ki-Bong [2 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 08826, South Korea
[2] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea
来源：
MARINE DRUGS | 2020年 / 18卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
marine-derived fungus; Aspergillussp; metabolites; sortase A; fibronectin; STAPHYLOCOCCUS-AUREUS; VIRULENCE; PROTEIN; SURFACE; TARGET; ADHESION; IRON; SRTA;
D O I：
10.3390/md18070359
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Seven alkaloidal compounds (2-8) and one polyketide (1) were isolated from a semisolid rice culture of the marine-derived fungusAspergillussp. F452. Structures of the isolated compounds were elucidated based on spectroscopic data and comparisons with previously reported data. The alkaloidal compounds (2-8) displayed weak to moderate inhibitory activities againstStaphylococcus aureus-derived sortase A (SrtA) without affecting cell viability. Aspermytin A (1) strongly inhibited SrtA activity, with an IC(50)value of 146.0 mu M, and significantly reduced bacterial adherence to fibronectin-coated surfaces. The present results indicate that the underlying mechanism of action of compound1is associated with the inhibition of SrtA-mediatedS.aureusadhesion to fibronectin, thus potentially serving as an SrtA inhibitor.
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页数：9
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