Cancer stem cells in osteosarcoma

被引：236
|
作者：
Brown, Hannah K. [1 ,2 ]
Tellez-Gabriel, Marta [3 ]
Heymann, Dominique [1 ,2 ,4 ]
机构：
[1] Univ Sheffield, Sch Med, Dept Oncol & Metab, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[2] Univ Sheffield, INSERM, European Associated Lab, Sarcoma Res Unit,Med Sch, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England
[3] Hosp Santa Creui St Pau, Inst Invest Biomed IBB St Pau, Lab Hematol Oncol & Transplantes, Barcelona 08025, Spain
[4] Univ Nantes, Fac Med, INSERM,Equipe Ligue 2012, UMR 957,Pathophysiol Bone Resorpt & Therapy Prima, F-44035 Nantes, France
来源：
CANCER LETTERS | 2017年 / 386卷
关键词：
Osteosarcoma; Bone cancer; Cancer stem cell; Tumour heterogeneity; SIDE POPULATION CELLS; DECIPHERING INTRATUMOR HETEROGENEITY; TUMOR-INITIATING CELLS; CD133; EXPRESSION; DRUG-RESISTANCE; BONE SARCOMAS; SELF-RENEWAL; SOLID TUMORS; ACTIVATION; DRIVER;
D O I：
10.1016/j.canlet.2016.11.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：189 / 195
页数：7
相关论文
共 50 条
  • [41] Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
    Bonuccelli, Gloria
    Avnet, Sofia
    Grisendi, Giulia
    Salerno, Manuela
    Granchi, Donatella
    Dominici, Massimo
    Kusuzaki, Katsuyuki
    Baldini, Nicola
    ONCOTARGET, 2014, 5 (17) : 7575 - 7588
  • [42] Leptin acts on mesenchymal stem cells to promote chemoresistance in osteosarcoma cells
    Feng, Helin
    Zhang, Qianqian
    Zhao, Yi
    Zhao, Lili
    Shan, Baoen
    AGING-US, 2020, 12 (07): : 6340 - 6351
  • [43] Osteosarcoma cells induce differentiation of mesenchymal stem cells into cancer associated fibroblasts through Notch and Akt signaling pathway
    Wang, Yu-Ming
    Wang, Wei
    Qiu, En-Duo
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (08): : 8479 - 8486
  • [44] Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment
    Aponte, Pedro M.
    Caicedo, Andres
    STEM CELLS INTERNATIONAL, 2017, 2017
  • [45] Design of naturally inspired jellyfish-shaped cyclopolylactides to manage osteosarcoma cancer stem cells fate
    Lienard, Romain
    Montesi, Monica
    Panseri, Silvia
    Dozio, Samuele Maria
    Vento, Fabiana
    Mineo, Placido G.
    Piperno, Anna
    De Winter, Julien
    Coulembier, Olivier
    Scala, Angela
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 117
  • [46] Immunology of Stem Cells and Cancer Stem Cells
    Xiao-Feng Yang1
    Cellular & Molecular Immunology, 2007, (03) : 161 - 171
  • [47] PTEN, Stem Cells, and Cancer Stem Cells
    Hill, Reginald
    Wu, Hong
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (18) : 11755 - 11759
  • [48] Immunology of stem cells and cancer stem cells
    Yang, Xiao-Feng
    CELLULAR & MOLECULAR IMMUNOLOGY, 2007, 4 (03) : 161 - 171
  • [49] Prostate Stem Cells and Cancer Stem Cells
    Li, Jia J.
    Shen, Michael M.
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2019, 9 (06):
  • [50] Forces in stem cells and cancer stem cells
    Chowdhury, Farhan
    Huang, Bo
    Wang, Ning
    CELLS & DEVELOPMENT, 2022, 170
12345