Olefin cross-metathesis in natural product synthesis:: preparation of trisubstituted olefins on the way to vitamin E

被引：0

作者：

Netscher, T ^{[1
]}

Malaisé, G ^{[1
]}

Bonrath, W ^{[1
]}

Breuninger, M ^{[1
]}

机构：

[1] DSM Nutr Prod, Res & Dev, CH-4002 Basel, Switzerland

来源：

ACTUALITE CHIMIQUE | 2006年

关键词：

ruthenium-catalysis; tocopherols; isoprenoids; E/Z selectivity; homo-coupling;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is described. This group of biologically most important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.

引用

页码：21 / 23

页数：3

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