Neurotoxicity of pesticides: its relationship with neurodegenerative diseases

被引：21

作者：

Thany, Steeve H. ^{[1
]}

Reynier, Pascal ^{[2
]}

Lenaers, Guy ^{[3
,4
]}

机构：

[1] Univ Angers, Lab Recepteurs & Canaux Ion Membranaires, UPRES EA USC INRA 2647 1330, UFR Sci, F-49045 Angers, France

[2] CHU Angers, Dept Biochim & Genet, Inserm 1083, Biol Neurovasc & Mitochondriale Integree UMR CNRS, F-49933 Angers 9, France

[3] Univ Montpellier I, Hop St Eloi, Inst Neurosci Montpellier,INSERM, Neuropathies Opt Hereditaires & Deficits Mitochon, F-34091 Montpellier, France

[4] Univ Montpellier 2, Hop St Eloi, Inst Neurosci Montpellier,INSERM, Neuropathies Opt Hereditaires & Deficits Mitochon, F-34091 Montpellier, France

来源：

M S-MEDECINE SCIENCES | 2013年 / 29卷 / 03期

关键词：

OXYGEN SPECIES PRODUCTION; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; COMPLEX-I; MICROGLIAL ACTIVATION; ROTENONE EXPOSURE; OXIDATIVE STRESS; SUBSTANTIA-NIGRA; PARAQUAT; DEGENERATION;

D O I：

10.1051/medsci/2013293013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Neurotoxicity of pesticides: its relationship with neurodegenerative diseases Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote a-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.

引用

页码：273 / 278

页数：6

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