Pulsatile Drug Release from PLGA Hollow Microspheres by Controlling the Permeability of Their Walls with a Magnetic Field

被引：72
|
作者：
Chiang, Wei-Lun [3 ]
Ke, Cherng-Jyh [3 ]
Liao, Zi-Xian [3 ]
Chen, San-Yuan [4 ]
Chen, Fu-Rong [5 ]
Tsai, Chun-Ying [5 ]
Xia, Younan [1 ,2 ]
Sung, Hsing-Wen [3 ]
机构：
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[2] Emory Univ, Atlanta, GA 30332 USA
[3] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan
[4] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 30013, Taiwan
[5] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu 30013, Taiwan
来源：
SMALL | 2012年 / 8卷 / 23期
关键词：
pulsatile drug release; molecular switches; magnetic stimulus; iron oxide nanoparticles; DELIVERY; DESIGN; SYSTEM; NANOPARTICLES;
D O I：
10.1002/smll.201201743
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3584 / 3588
页数：5
相关论文
共 50 条
  • [21] Heuristic modeling of macromolecule release from PLGA microspheres
    Szlek, Jakub
    Paclawski, Adam
    Lau, Raymond
    Jachowicz, Renata
    Mendyk, Aleksander
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2013, 8 : 4601 - 4611
  • [22] Microfluidic preparation of monodisperse PLGA-PEG/PLGA microspheres with controllable morphology for drug release
    Chen, Wenwen
    Li, Hao
    Zhang, Xinyue
    Sang, Yutao
    Nie, Zhihong
    LAB ON A CHIP, 2024, 24 (19) : 4623 - 4631
  • [23] Blending of PLGA-PEG-PLGA for Improving the Erosion and Drug Release Profile of PCL Microspheres
    Wang, Siyuan
    Feng, Xiaobo
    Liu, Ping
    Wei, Youxiu
    Xiao, Baojun
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2020, 21 (11) : 1079 - 1087
  • [24] Comparison in Drug Release Behaviors of Monodisperse PLGA Microspheres with Different Sizes
    Wu, J.
    Yeung, K.
    To, M.
    TISSUE ENGINEERING PART A, 2014, 20 : S78 - S79
  • [25] Extended release of recombinant adenovirus from PLGA microspheres
    Hilfinger, JM
    Tsume, Y
    Beer, S
    Davidson, B
    Crison, JR
    Amidon, GL
    23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, : 915 - 916
  • [26] Effect of hydroxyethyl starch on drug stability and release of semaglutide in PLGA microspheres
    Zeng, Han
    Song, Jiaxin
    Li, Yiyao
    Guo, Chen
    Zhang, Yu
    Yin, Tian
    He, Haibing
    Gou, Jingxin
    Tang, Xing
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2024, 654
  • [27] Investigation of radiofrequency induced release kinetics from magnetic hollow silica microspheres
    Kovacik, Pavel
    Kremlackova, Zuzana
    Stepanek, Frantisek
    MICROPOROUS AND MESOPOROUS MATERIALS, 2012, 159 : 119 - 125
  • [28] A novel study on the mechanisms of drug release in PLGA-mPEG microspheres with fluorescent drug
    Shi, Chen
    Feng, Shuibin
    Liu, Ping
    Liu, Xianzhe
    Feng, Xiaobo
    Fu, Dehao
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2016, 27 (09) : 854 - 864
  • [29] Drug Release from PLGA Microspheres Attached to Solids Using Supercritical CO2
    Mulia, Kamarza
    Witkamp, Geert-jan
    Dawes, Gwen J. S.
    Fratila-Apachitei, Lidy Elena
    Apachitei, Iulian
    Duszczyk, Jurek
    Pellikaan, Hubert
    JOURNAL OF BIOMATERIALS APPLICATIONS, 2011, 25 (05) : 401 - 412
  • [30] Fabrication of hollow porous PLGA microspheres for controlled protein release and promotion of cell compatibility
    Guo-Hua Zhang
    Rui-Xia Hou
    Dan-Xia Zhan
    Yang Cong
    Ya-Jun Cheng
    Jun Fu
    Chinese Chemical Letters, 2013, 24 (08) : 710 - 714
12345