Synthesis of Hydroxamic Acids by Using the Acid Labile O-2-Methylprenyl Protecting Group

被引：6
|
作者：
Nikitjuka, Anna [1 ]
Jirgensons, Aigars [1 ]
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
来源：
SYNLETT | 2012年 / 20期
关键词：
protecting groups; cleavage; carboxylic acids; hydroxamic acids; hydroxylamine; ALPHA CONVERTING-ENZYME; HISTONE DEACETYLASE INHIBITORS; BIOLOGICAL EVALUATION; DISCOVERY;
D O I：
10.1055/s-0032-1317687
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Coupling of carboxylic acids with O-2-methylprenyl hydroxylamine provided O-protected hydroxamic acids, which could be deprotected by treatment with trifluoroacetic acid (TFA) in di-chloromethane giving volatile by-products. Protected hydroxamic acids could be N-arylated or alkylated followed by deprotection to give N-substituted hydroxamic acids.
引用
收藏
页码：2972 / 2974
页数：3
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