Synthesis of Hydroxamic Acids by Using the Acid Labile O-2-Methylprenyl Protecting Group

被引：6

作者：

Nikitjuka, Anna ^{[1
]}

Jirgensons, Aigars ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

SYNLETT | 2012年 / 20期

关键词：

protecting groups; cleavage; carboxylic acids; hydroxamic acids; hydroxylamine; ALPHA CONVERTING-ENZYME; HISTONE DEACETYLASE INHIBITORS; BIOLOGICAL EVALUATION; DISCOVERY;

D O I：

10.1055/s-0032-1317687

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coupling of carboxylic acids with O-2-methylprenyl hydroxylamine provided O-protected hydroxamic acids, which could be deprotected by treatment with trifluoroacetic acid (TFA) in di-chloromethane giving volatile by-products. Protected hydroxamic acids could be N-arylated or alkylated followed by deprotection to give N-substituted hydroxamic acids.

引用

页码：2972 / 2974

页数：3

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