Functional interactions between the gut microbiota and host metabolism

被引：3315
|
作者：
Tremaroli, Valentina [1 ,2 ]
Backhed, Fredrik [1 ,2 ,3 ]
机构：
[1] Sahlgrens Univ Hosp, Wallenberg Lab Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden
[2] Univ Gothenburg, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden
[3] Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark
来源：
NATURE | 2012年 / 489卷 / 7415期
基金：
瑞典研究理事会;
关键词：
DIET-INDUCED OBESITY; PROTEIN-COUPLED RECEPTOR; CHAIN FATTY-ACIDS; ADIPOSE-TISSUE; BILE-ACIDS; INDUCED INFLAMMATION; INSULIN-RESISTANCE; ENERGY-METABOLISM; BARIATRIC SURGERY; IMMUNE-SYSTEM;
D O I：
10.1038/nature11552
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.
引用
收藏
页码：242 / 249
页数：8
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