Relationship of energy metabolism detected by 31P-MRS in the human brain with mental fatigue

To search for a possible relationship between brain energy metabolism and mental fatiguability, 10 normal volunteers were examined by P-31-MRS (phosphorus-31 magnetic resonance spectroscopy) in the occipital cortex during photic stimulation (PS), and Uchida-Kraepelin test (UKT), a standardized serial calculation task, was used for measurement of intraindividual characteristics of mental fatigue in these subjects. More decrease of phosphocreatine measured by P-31-MRS during the PS was significantly associated with more effects of rest assessed by UKT (r = -0.86, p <0.005), More decrease in pH after PS was associated with steeper decline of performance (r = 0.78, p <0.01). These findings suggest that characteristics of brain energy metabolism in an individual may relate to intrinsic patterns of mental fatigability.