Effect of long-term administration of berberine on scopolamine-induced amnesia in rats

被引：52
|
作者：
Peng, WH
Hsieh, MT
Wu, CR
机构：
[1] Inst. of Chinese Pharmaceutical Sci., China Medical College, Taichung, 91, Hsueh Shih Road
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 74卷 / 03期
关键词：
berberine; scopolamine; passive avoidance;
D O I：
10.1254/jjp.74.261
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of berberine (BER) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that BER at the doses of 0.1 and 0.5 g/kg after 7-day or 14-day administration significantly improved SCOP-induced amnesia. The anti-amnesic effect of BER after 14-day administration on the SCOP-induced amnesia was significantly augmented by physostigmine or neostigmine, and completely reversed by scopolamine N-methylbromide. These results suggest that the antiamnesic effect of BER after 14-day administration may be related to the increase in the peripheral and central cholinergic neuronal system activity.
引用
收藏
页码：261 / 266
页数：6
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