Human Atrial Fibrillation: Insights From Computational Electrophysiological Models

被引：22
|
作者：
Bers, Donald M. [1 ]
Grandi, Eleonora [1 ]
机构：
[1] Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2011年 / 21卷 / 05期
关键词：
OUTWARD K+ CURRENT; MOLECULAR DETERMINANTS; MATHEMATICAL-MODEL; IONIC MECHANISMS; REDOX REGULATION; MYOCYTES; CURRENTS; CHANNELS; REFRACTORINESS; ACETYLCHOLINE;
D O I：
10.1016/j.tcm.2012.04.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Computational electrophysiology has proven useful to investigate the mechanisms of cardiac arrhythmias at various spatial scales, from isolated myocytes to the whole heart. This article reviews how mathematical modeling has aided our understanding of human atrial myocyte electrophysiology to study the contribution of structural and electrical remodeling to human atrial fibrillation. Potential new avenues of investigation and model development are suggested. (Trends Cardiovasc Med 2011;21:145-150) (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：145 / 150
页数：6
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