FECAL LACTOFERRIN AS A NONINVASIVE BIOMARKER IN INFLAMMATORY BOWEL DISEASES

被引：25
|
作者：
Langhorst, J. [1 ]
Boone, J. [2 ]
机构：
[1] Univ Duisburg Essen, Kliniken Essen Mitte, Dept Internal & Integrat Med, D-45276 Essen, Germany
[2] TechLab, Res & Dev, Blacksburg, VA USA
来源：
DRUGS OF TODAY | 2012年 / 48卷 / 02期
关键词：
Lactoferrin; Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; Fecal biomarkers; NEUTROPHIL-DERIVED PROTEINS; C-REACTIVE PROTEIN; CROHNS-DISEASE; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; YOUNG-ADULTS; ILEAL POUCH; CALPROTECTIN; MARKERS; PARAMETERS;
D O I：
10.1358/dot.2012.48.2.1732555
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The diagnosis and management of inflammatory bowel diseases (IBD), i.e., Crohn's disease and ulcerative colitis, still present a number of challenges. The fecal biomarker lactoferrin has been shown to be useful in the diagnosis and management of these diseases. This review includes a discussion of the current literature on lactoferrin as a biomarker of intestinal disease, detection of disease activity in 1130, comparison of lactoferrin to endoscopy and histology, lactoferrin measurement in pediatric IBD and lactoferrin as a biomarker for monitoring medical treatment in IBD.
引用
收藏
页码：149 / 161
页数：13
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