FECAL LACTOFERRIN AS A NONINVASIVE BIOMARKER IN INFLAMMATORY BOWEL DISEASES

被引：25

作者：

Langhorst, J. ^{[1
]}

Boone, J. ^{[2
]}

机构：

[1] Univ Duisburg Essen, Kliniken Essen Mitte, Dept Internal & Integrat Med, D-45276 Essen, Germany

[2] TechLab, Res & Dev, Blacksburg, VA USA

来源：

DRUGS OF TODAY | 2012年 / 48卷 / 02期

关键词：

Lactoferrin; Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; Fecal biomarkers; NEUTROPHIL-DERIVED PROTEINS; C-REACTIVE PROTEIN; CROHNS-DISEASE; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; YOUNG-ADULTS; ILEAL POUCH; CALPROTECTIN; MARKERS; PARAMETERS;

D O I：

10.1358/dot.2012.48.2.1732555

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The diagnosis and management of inflammatory bowel diseases (IBD), i.e., Crohn's disease and ulcerative colitis, still present a number of challenges. The fecal biomarker lactoferrin has been shown to be useful in the diagnosis and management of these diseases. This review includes a discussion of the current literature on lactoferrin as a biomarker of intestinal disease, detection of disease activity in 1130, comparison of lactoferrin to endoscopy and histology, lactoferrin measurement in pediatric IBD and lactoferrin as a biomarker for monitoring medical treatment in IBD.

引用

页码：149 / 161

页数：13

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