Glutathione redox regulates TGF-β-induced fibrogenic effects through Smad3 activation

被引：21

作者：

Ono, Akihiro ^{[1
]}

Utsugi, Mitsuyoshi ^{[1
]}

Masubuchi, Ken ^{[1
]}

Ishizuka, Tamotsu ^{[1
]}

Kawata, Tadayoshi ^{[1
]}

Shimizu, Yasuo ^{[1
]}

Hisada, Takeshi ^{[1
]}

Hamuro, Junji ^{[2
]}

Mori, Masatomo ^{[1
]}

Dobashi, Kunio ^{[3
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan

[2] Keio Univ, Sch Med, Dept Microbiol & Immunol, Tokyo, Japan

[3] Gunma Univ, Fac Med, Sch Hlth Sci, Maebashi, Gunma 3718511, Japan

来源：

FEBS LETTERS | 2009年 / 583卷 / 02期

关键词：

Glutathione redox; Transforming growth factor-beta; Smad; Fibrogenic effect; Human lung fibroblast; Bronchial smooth muscle cell; TISSUE GROWTH-FACTOR; SMOOTH-MUSCLE CELLS; TRANSFORMING GROWTH-FACTOR-BETA-1; EXTRACELLULAR-MATRIX; EXPRESSION; BINDING; RANTES; MODEL; P38;

D O I：

10.1016/j.febslet.2008.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-beta (TGF-beta) plays a pivotal role in the fibrogenic action involved in theinduction of connective tissue growth factor (CTGF), extracellular matrix and fibroblast transformation. Smad3 mediates TGF-beta signaling related to the fibrotic response. In human lung fibroblasts or bronchial smooth muscle cells, we demonstrated that an increase in the intracellular glutathione level suppressed TGF-beta 1-induced phosphorylation of Smad3, while inhibiting TGF-beta 1-induced expressions of CTGF, collagen type1, fibronectin and transformation into myofibroblasts, which are characterized by the expression of alpha-smooth muscle actin. These data indicate that the intracellular glutathione redox status regulates TGF-beta-induced fibrogenic effects through Smad3 activation. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：357 / 362

页数：6

共 50 条

[41] Targeted dephosphorylation of SMAD3 as an approach to impede TGF- β signaling
Brewer, Abigail
Zhao, Jin-Feng
Fasimoye, Rotimi
Shpiro, Natalia
Macartney, Thomas J.
Wood, Nicola T.
Wightman, Melanie
Alessi, Dario R.
Sapkota, Gopal P.
ISCIENCE, 2024, 27 (08)
[42] Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells
Yang, Yue
Kim, Bohkyung
Park, Young-Ki
Koo, Sung I.
Lee, Ji-Young
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 1850 (01): : 178 - 185
[43] STAT3 selectively interacts with Smad3 to antagonize TGF-β
G Wang
Y Yu
C Sun
T Liu
T Liang
L Zhan
X Lin
X-H Feng
Oncogene, 2016, 35 : 4388 - 4398
[44] TGF-β and Smad3 signaling link inflammation to chronic fibrogenesis
Bonniaud, P
Margetts, PJ
Ask, K
Flanders, K
Gauldie, J
Kolb, M
JOURNAL OF IMMUNOLOGY, 2005, 175 (08): : 5390 - 5395
[45] Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF-β/Smad3 Pathway
Huang, Xin-Zhong
Wen, Donghai
Zhang, Min
Xie, Qionghong
Ma, Leting
Guan, Yi
Ren, Yueheng
Chen, Jing
Hao, Chuan-Ming
JOURNAL OF CELLULAR BIOCHEMISTRY, 2014, 115 (05) : 996 - 1005
[46] Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-β/Smad3-mediated transcriptional activation
Pei-Lin Cheng
Meng-Hsiung Chang
Chi-Hong Chao
Yan-Hwa Wu Lee
Oncogene, 2004, 23 : 7821 - 7838
[47] Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-β/Smad3-mediated transcriptional activation
Cheng, PL
Chang, MH
Chao, CH
Lee, YHW
ONCOGENE, 2004, 23 (47) : 7821 - 7838
[48] ATF-2 cooperates with Smad3 to mediate TGF-β effects on chondrocyte maturation
Ionescu, AM
Schwarz, EM
Zuscik, MJ
Drissi, H
Puzas, JE
Rosier, RN
O'Keefe, RJ
EXPERIMENTAL CELL RESEARCH, 2003, 288 (01) : 198 - 207
[49] BRCA1 Interacts with Smad3 and Regulates Smad3-Mediated TGF-β Signaling during Oxidative Stress Responses
Li, Huchun
Sekine, Masayuki
Seng, Seyha
Avraham, Shalom
Avraham, Hava Karsenty
PLOS ONE, 2009, 4 (09):
[50] TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
Shen, X
Hu, PP
Liberati, NT
Datto, MB
Frederick, JP
Wang, XF
MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (12) : 3309 - 3319

← 1 2 3 4 5 →