Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents

被引：28

作者：

Davies, Stephen G. ^{[1
]}

Fletcher, Ai M. ^{[1
]}

Thomson, James E. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 77期

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; STEREOSELECTIVE TOTAL-SYNTHESIS; GROB-TYPE FRAGMENTATIONS; 1ST TOTAL-SYNTHESIS; BETA-AMINO KETONES; ALDOL REACTIONS; ENANTIOMERICALLY PURE; ALPHA-ALKYLATION; DIASTEREOSELECTIVE SYNTHESIS; CYCLIZATION REACTIONS;

D O I：

10.1039/c3cc45463k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article covers N-acyl chiral auxiliary-based approaches to the asymmetric synthesis of enantiopure aldehydes and ketones. The use of diastereoisomerically pure N-acyl derivatives of chiral auxiliaries (including chiral Weinreb amide equivalents) and their conversion to the corresponding enantiopure aldehydes and ketones in a single synthetic operation by treatment with a hydride reducing agent or an organometallic reagent, respectively, are highlighted.

引用

页码：8586 / 8598

页数：13

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