Inhibition of HSP90 with NVP-AUY922 induces a synergistic effect in HER2-amplified, trastuzumab-resistant breast and gastric cancer

被引:0
|
作者
Wainberg, Zev A. [1 ]
Rogers, Amy [1 ]
O'Brien, Neil [1 ]
Anghel, Adrian [1 ]
Desai, Amrita [1 ]
Kalous, Ondrej [1 ]
Conklin, Dylan [1 ]
Akimov, Mikhail [2 ]
Finn, Richard S. [1 ]
Slamon, Dennis J. [1 ]
机构
[1] Univ Calif Los Angeles, Med Ctr Santa Monica, Santa Monica, CA USA
[2] Novartis, Basel, Switzerland
关键词
D O I
10.1158/1538-7445.AM2012-3668
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3668
引用
收藏
页数:1
相关论文
共 50 条
  • [41] HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2
    Yang, Hannah
    Lee, Mi-Hee
    Park, Intae
    Jeon, Hanwool
    Choi, Junyoung
    Seo, Seyoung
    Kim, Sang-We
    Koh, Gou Young
    Park, Kang-Seo
    Lee, Dae Ho
    CANCER LETTERS, 2017, 411 : 19 - 26
  • [42] Simultaneous radiation and Hsp90 inhibition by NVP-AUY922 or NVP-BEP800 is more efficient in tumor cell killing than drug-first modality followed by irradiation
    Niewidok, N.
    Wack, L-J
    Stingl, L.
    Katzer, A.
    Sukhorukov, V. L.
    Flentje, M.
    Djuzenova, C. S.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2011, 187 : 125 - 126
  • [43] The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer
    Park, Minsu
    Jung, Eunsun
    Park, Jung Min
    Park, Soeun
    Ko, Dongmi
    Seo, Juyeon
    Kim, Seongjae
    Nam, Kee Dal
    Kang, Yong Koo
    Farrand, Lee
    Hoang, Van-Hai
    Nguyen, Cong-Truong
    La, Minh Thanh
    Nam, Gibeom
    Park, Hyun-Ju
    Ann, Jihyae
    Lee, Jeewoo
    Kim, Yoon-Jae
    Kim, Ji Young
    Seo, Jae Hong
    THERANOSTICS, 2024, 14 (06): : 2442 - 2463
  • [44] The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib
    Park, Kang-Seo
    Oh, Bora
    Lee, Mi-Hee
    Nam, Ky-Youb
    Jin, Hae Ran
    Yang, Hannah
    Choi, Junyoung
    Kim, Sang -We
    Lee, Dae Ho
    CANCER LETTERS, 2016, 372 (01) : 75 - 81
  • [45] Identification of predictors of response to NVP-AUY922, an HSP90 inhibitor, in an in vitro panel of human non-small-cell lung cancer (NSCLC) cell lines
    Garon, Edward B.
    Finn, Richard S.
    Dering, Judy
    Ginther, Charles
    Adhami, Shariar
    Pitts, Sharon
    Kamranpour, Naeimeh
    Hosmer, Wylie
    Jensen, Rugaard Michael
    Quadt, Cornelia
    Slamon, Dennnis J.
    JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S599 - S599
  • [46] Radiation response of tumor cell lines after combined MEK and Hsp90 inhibition by PD184352 and NVP-AUY922: The role of drug-irradiation schedule
    Grabenbauer, F.
    Katzer, A.
    Fiedler, V
    Flentje, M.
    Djuzenova, C. S.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2015, 191 : S91 - S91
  • [47] THE INFLUENCE OF THE HEAT SHOCK PROTEIN 90 (HSP90) INHIBITOR, NVP-AUY922, AND HYPOXIA ON THE EXPRESSION OF HIF-1α AND HIF-2α IN TWO HEAD AND NECK CANCER CELL LINES
    Bayer, C.
    Schilling, D.
    Multhoff, G.
    RADIOTHERAPY AND ONCOLOGY, 2012, 102 : S119 - S119
  • [48] Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth
    Chandarlapaty, S.
    Scaltriti, M.
    Angelini, P.
    Ye, Q.
    Guzman, M.
    Hudis, C. A.
    Norton, L.
    Solit, D. B.
    Arribas, J.
    Baselga, J.
    Rosen, N.
    ONCOGENE, 2010, 29 (03) : 325 - 334
  • [49] Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth
    S Chandarlapaty
    M Scaltriti
    P Angelini
    Q Ye
    M Guzman
    C A Hudis
    L Norton
    D B Solit
    J Arribas
    J Baselga
    N Rosen
    Oncogene, 2010, 29 : 325 - 334
  • [50] HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells
    Lee, Dae-Hee
    Sung, Ki Sa
    Bartlett, David L.
    Kwon, Yong Tae
    Lee, Yong J.
    CELLULAR SIGNALLING, 2015, 27 (02) : 293 - 305