Recent Progresses in the Synthesis of Taxol

被引：4
|
作者：
Tang, Pei [1 ,2 ]
Wang, Fengpeng [2 ]
机构：
[1] Chongqing Univ, Bioengn Coll, Innovat Drug Res Ctr, Chongqing 401331, Peoples R China
[2] Sichuan Univ, West China Coll Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 03期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
taxol; synthesis; progress; ENANTIOSELECTIVE TOTAL-SYNTHESIS; 1ST TOTAL-SYNTHESIS; STEREOCONTROLLED SYNTHESIS; SIDE-CHAIN; AB-RING; CONSTRUCTION; COMPLETION; STRATEGY; TAXANES; ANALOGS;
D O I：
10.6023/cjoc201209033
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Taxol and docetaxel are currently the largest selling anticancer drugs. Numerous elegant studies about taxol and its analogues have been reported recently. In this review, the recent progresses in the synthesis of taxol are summarized. These examples cover the synthetic studies of the 6-8-6 tricyclic core, ring system, and side chain.
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收藏
页码：458 / 468
页数：11
相关论文
共 47 条
  • [1] Toward an efficient synthesis of taxane analogs by dienyne ring-closing metathesis
    Aldegunde, Maria J.
    Castedo, Luis
    Granja, Juan R.
    [J]. ORGANIC LETTERS, 2008, 10 (17) : 3789 - 3792
  • [2] [Anonymous], 1995, TAXOL SCI APPL
  • [3] Highly efficient stereocontrolled synthesis of Danishefsky's taxol CD ring key intermediate
    Bremond, Paul
    Audran, Gerard
    Monti, Honore
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2008, 73 (15): : 6033 - 6036
  • [4] Chen Q. H., 2001, NAT PROD RES DEV, V13, P88
  • [5] Total synthesis of baccatin III and taxol
    Danishefsky, SJ
    Masters, JJ
    Young, WB
    Link, JT
    Snyder, LB
    Magee, TV
    Jung, DK
    Isaacs, RCA
    Bornmann, WG
    Alaimo, CA
    Coburn, CA
    DiGrandi, MJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (12) : 2843 - 2859
  • [6] A formal total synthesis of taxol aided by an automated synthesizer
    Doi, Takayuki
    Fuse, Shinichiro
    Miyamoto, Shigeru
    Nakai, Kazuoki
    Sasuga, Daisuke
    Takahashi, Takashi
    [J]. CHEMISTRY-AN ASIAN JOURNAL, 2006, 1 (03) : 370 - 383
  • [7] Highly Enantioselective Organocatalytic Addition of Aldehydes to N-(Phenylmethylene)benzamides: Asymmetric Synthesis of the Paclitaxel Side Chain and Its Analogues
    Dziedzic, Pawel
    Schyman, Patric
    Kullberg, Martin
    Cordova, Armando
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (16) : 4044 - 4048
  • [8] A novel route for the construction of Taxol ABC-ring framework: skeletal rearrangement approach to AB-ring and intramolecular aldol approach to C-ring
    Enomoto, Terumichi
    Morimoto, Tsumoru
    Ueno, Mifuyu
    Matsukubo, Takanori
    Shimada, Yumi
    Tsutsumi, Ken
    Shirai, Ryuichi
    Kakiuchi, Kiyomi
    [J]. TETRAHEDRON, 2008, 64 (18) : 4051 - 4059
  • [9] cis-(-)-Menthyl phenylglycidates in the asymmetric synthesis of taxol side chain
    Er, Mustafa
    Coskun, Necdet
    [J]. ARKIVOC, 2009, : 153 - 160
  • [10] Fang WS, 1994, CHIN PHARM J, V29, P259
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