Toward an efficient synthesis of taxane analogs by dienyne ring-closing metathesis

被引：28

作者：

Aldegunde, Maria J. ^{[1
]}

Castedo, Luis ^{[1
]}

Granja, Juan R. ^{[1
]}

机构：

[1] Univ Santiago, Dept Quim Organ, Fac Quim, Labs CSIC, Santiago De Compostela 15782, Spain

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 17期

关键词：

D O I：

10.1021/ol801469h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient tandem ring-closing dienyne metathesis of dienynes derived from cyclohex-2-enone affords the [5.3.1] carbon framework characteristic of taxanes in a single-step process. Further stereoselective functionalizations of the resulting [5.3.1] carbon framework lead to an advanced intermediate in a novel synthetic strategy for taxane analogs.

引用

页码：3789 / 3792

页数：4

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