Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications

被引：9

作者：

Oh, Seung-Ick ^{[1
]}

Lee, Chang Kyu ^{[1
]}

Cho, Kyung Jin ^{[1
]}

Lee, Kyung-Ok ^{[2
]}

Cho, Ssang-Goo ^{[3
,4
]}

Hong, Sunghoi ^{[1
]}

机构：

[1] Korea Univ, Dept Biomed Sci, Coll Hlth Sci, Seoul 136703, South Korea

[2] NeoDIN Med Inst, Div Stem Cell Res, Seoul 133847, South Korea

[3] Konkuk Univ, Dept Anim Biotechnol, Seoul 143701, South Korea

[4] Konkuk Univ, Anim Resources Res Ctr, Seoul 143701, South Korea

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

基金：

新加坡国家研究基金会;

关键词：

HUMAN SOMATIC-CELLS; EPSTEIN-BARR-VIRUS; STABLE REPLICATION; DEFINED FACTORS; MOUSE; INDUCTION; VECTOR; ADULT; OCT4; DIFFERENTIATION;

D O I：

10.1100/2012/417809

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.

引用

页数：10

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