Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications

被引：9
|
作者：
Oh, Seung-Ick [1 ]
Lee, Chang Kyu [1 ]
Cho, Kyung Jin [1 ]
Lee, Kyung-Ok [2 ]
Cho, Ssang-Goo [3 ,4 ]
Hong, Sunghoi [1 ]
机构：
[1] Korea Univ, Dept Biomed Sci, Coll Hlth Sci, Seoul 136703, South Korea
[2] NeoDIN Med Inst, Div Stem Cell Res, Seoul 133847, South Korea
[3] Konkuk Univ, Dept Anim Biotechnol, Seoul 143701, South Korea
[4] Konkuk Univ, Anim Resources Res Ctr, Seoul 143701, South Korea
来源：
SCIENTIFIC WORLD JOURNAL | 2012年
基金：
新加坡国家研究基金会;
关键词：
HUMAN SOMATIC-CELLS; EPSTEIN-BARR-VIRUS; STABLE REPLICATION; DEFINED FACTORS; MOUSE; INDUCTION; VECTOR; ADULT; OCT4; DIFFERENTIATION;
D O I：
10.1100/2012/417809
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] Recent technological updates and clinical applications of induced pluripotent stem cells
    Diecke, Sebastian
    Jung, Seung Min
    Lee, Jaecheol
    Ju, Ji Hyeon
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2014, 29 (05): : 547 - 557
  • [2] Human-Induced Pluripotent Stem Cell Technology and Cardiomyocyte Generation: Progress and Clinical Applications
    Di Baldassarre, Angela
    Cimetta, Elisa
    Bollini, Sveva
    Gaggi, Giulia
    Ghinassi, Barbara
    CELLS, 2018, 7 (06)
  • [3] The Progress of Induced Pluripotent Stem Cells (iPSCs) for Research and Applications
    Fu Yu-Hua
    Zhou Xiu-Mei
    Xu Feng-Qing
    Qian Qi-Jun
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2011, 38 (02) : 101 - 112
  • [4] Clinical Applications of Induced Pluripotent Stem Cells - Stato Attuale
    Kavyasudha, Chavali
    Macrin, Dannie
    ArulJothi, K. N.
    Joseph, Joel P.
    Harishankar, M. K.
    Devi, Arikketh
    CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 1: STEM CELLS IN REGENERATIVE MEDICINE: ADVANCES AND CHALLENGES, 2018, 1079 : 127 - 149
  • [5] Induced Pluripotent Stem Cells and Their Applications
    Sevim, Handan
    Gurpinar, Ozer Aylin
    MARMARA MEDICAL JOURNAL, 2012, 25 (01): : 5 - 9
  • [6] Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
    Zhao, Chengzhu
    Ikeya, Makoto
    STEM CELLS INTERNATIONAL, 2018, 2018
  • [7] Human-Induced Pluripotent Stem Cells: In Quest of Clinical Applications
    Rosalinda Madonna
    Molecular Biotechnology, 2012, 52 : 193 - 203
  • [8] Induced pluripotent stem cells: From Nobel Prizes to clinical applications
    Rashid, S. Tamir
    Alexander, Graeme J. M.
    JOURNAL OF HEPATOLOGY, 2013, 58 (03) : 625 - 629
  • [9] Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles
    Panopoulos, Athanasia D.
    Belmonte, Juan C. I.
    CURRENT OPINION IN HEMATOLOGY, 2012, 19 (04) : 256 - 260
  • [10] Human-Induced Pluripotent Stem Cells: In Quest of Clinical Applications
    Madonna, Rosalinda
    MOLECULAR BIOTECHNOLOGY, 2012, 52 (02) : 193 - 203
12345