Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG)

被引：8
|
作者：
Metea, Monica [1 ]
Litwak, Mona [2 ]
Arezzo, Joseph [2 ,3 ]
机构：
[1] Smithers Viscient Labs, Lexington, MA USA
[2] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY USA
[3] Albert Einstein Coll Med, Dept Neurol, Bronx, NY USA
来源：
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 2015年 / 75卷
关键词：
Convulsions; EEG spectral analysis; Electromyography/EMG; Regulatory drug development; Safety pharmacology; Seizure; Sharp waves; Preclinical seizure risk assessment; Premonitory signs; Telemetry; Tremors; Video-EEG; HIGH-FREQUENCY OSCILLATIONS; EVENT-RELATED POTENTIALS; CURRENT ANIMAL-MODELS; SAFETY PHARMACOLOGY; ANTIEPILEPTIC DRUGS; EPILEPTIC SEIZURES; QUANTITATIVE EEG; PREICTAL STATE; BRAIN; ANTICONVULSANT;
D O I：
10.1016/j.vascn.2015.04.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
[No abstract available]
引用
收藏
页码：135 / 142
页数：8
相关论文
共 50 条
  • [21] Infantile Spasms: An Update on Pre-Clinical Models and EEG Mechanisms
    Janicot, Remi
    Shao, Li-Rong
    Stafstrom, Carl E.
    [J]. CHILDREN-BASEL, 2020, 7 (01):
  • [22] Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies
    Annese, Tiziana
    Tamma, Roberto
    Ruggieri, Simona
    Ribatti, Domenico
    [J]. CANCERS, 2019, 11 (03)
  • [23] Neonatal encephalopathy: pre-clinical studies in neuroprotection
    Patel, Shyama D.
    Pierce, Leslie
    Ciardiello, Amber J.
    Vannucci, Susan J.
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2014, 42 : 564 - 568
  • [24] Pre-clinical autoimmunity and IDDM disease risk
    Tait, BD
    Marchinovska, L
    Dore, E
    Colman, P
    Gellert, S
    Morahan, G
    Stephens, K
    Toth, A
    Holdsworth, R
    McCluskey, J
    [J]. TISSUE ANTIGENS, 2002, 59 : 16 - 16
  • [25] Pre-clinical studies with tumor suppressor genes
    Seth, P
    [J]. CANCER GENE THERAPY, 2000, 465 : 183 - 192
  • [26] MicroRNAs and fracture healing: Pre-clinical studies
    Komatsu, David E.
    Duque, Edie
    Hadjiargyrou, Michael
    [J]. BONE, 2021, 143
  • [27] Sexual dimorphism in pre-clinical studies of depression
    Alshammari, Tahani K.
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2021, 105
  • [28] Pre-clinical studies of BRAF signalling in cancer
    Marais, R.
    [J]. EJC SUPPLEMENTS, 2007, 5 (04): : 44 - 45
  • [29] Immunotoxins and other conjugates: Pre-clinical studies
    Bolognesi, A
    Polito, L
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2004, 4 (05) : 563 - 583
  • [30] RH1, pre-clinical studies
    Hargreaves, RHJ
    Winski, SL
    Ross, D
    Alley, M
    Sausville, EA
    McGown, AT
    Butler, J
    [J]. BRITISH JOURNAL OF CANCER, 1999, 80 : 95 - 95
12345