Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG)

被引：8
|
作者：
Metea, Monica [1 ]
Litwak, Mona [2 ]
Arezzo, Joseph [2 ,3 ]
机构：
[1] Smithers Viscient Labs, Lexington, MA USA
[2] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY USA
[3] Albert Einstein Coll Med, Dept Neurol, Bronx, NY USA
来源：
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 2015年 / 75卷
关键词：
Convulsions; EEG spectral analysis; Electromyography/EMG; Regulatory drug development; Safety pharmacology; Seizure; Sharp waves; Preclinical seizure risk assessment; Premonitory signs; Telemetry; Tremors; Video-EEG; HIGH-FREQUENCY OSCILLATIONS; EVENT-RELATED POTENTIALS; CURRENT ANIMAL-MODELS; SAFETY PHARMACOLOGY; ANTIEPILEPTIC DRUGS; EPILEPTIC SEIZURES; QUANTITATIVE EEG; PREICTAL STATE; BRAIN; ANTICONVULSANT;
D O I：
10.1016/j.vascn.2015.04.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
[No abstract available]
引用
收藏
页码：135 / 142
页数：8
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