New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia

被引：39
|
作者：
Jiang, Bei [1 ,2 ]
Wang, Wen-Jing [1 ,2 ]
Li, Man-Ping [1 ]
Huang, Xiao-Jun [1 ,2 ]
Huang, Feng [1 ]
Gao, Hao [1 ,2 ]
Sun, Ping-Hua [1 ]
He, Ming-Fang [3 ]
Jiang, Zheng-Jin [1 ]
Zhang, Xiao-Qi [1 ,2 ]
Ye, Wen-Cai [1 ,2 ]
机构：
[1] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
[3] Nanjing Univ Technol, Sch Pharmaceut Sci, Sinoamer Canc Ctr, Nanjing 210009, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Alpinia oxyphylla; Zingiberaceae; Noreudesmane sesquiterpenoid; Microglia; Neuroprotection; NITRIC-OXIDE PRODUCTION; ABSOLUTE STEREOSTRUCTURES; FRUITS; NOOTKATONE; LACTONES; NEURONS; FRUCTUS;
D O I：
10.1016/j.bmcl.2013.04.072
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1-3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3879 / 3883
页数：5
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