Alzheimer Aβ vaccination of rhesus monkeys (Macaca mulatta)

被引：22

作者：

Gandy, S

DeMattos, RB

Lemere, CA

Heppner, FL

Leverone, J

Aguzzi, A

Ershler, WB

Dai, JL

Fraser, P

Hyslop, PS

Holtzman, DM

Walker, LC

Keller, ET

机构：

[1] Thomas Jefferson Univ, Farber Inst Neurosci, Philadelphia, PA 19107 USA

[2] Washington Univ, St Louis, MO 63130 USA

[3] Harvard Med Inst, Boston, MA USA

[4] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[5] Univ Zurich, CH-8006 Zurich, Switzerland

[6] Inst Adv Studies Aging & Geriatr Med, Washington, DC USA

[7] Univ Michigan, Dept Lab Anim Med, Ann Arbor, MI 48109 USA

[8] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[9] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2004年 / 18卷 / 01期

关键词：

amyloid; immunoglobulin G; cytokine;

D O I：

10.1097/00002093-200401000-00009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent preliminary data suggest that vaccination with Alzheimer AD might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta1-42. Immunized monkeys developed anti-Abeta titers exceeding 1: 1000, and their plasma Abeta levels were 5- to 10-fold higher than the plasma AD levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer AD.

引用

页码：44 / 46

页数：3

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