Design and synthesis of some isoindoline derivatives as analogues of the active anti-inflammatory Indoprofen

被引：17

作者：

Csende, Ferenc ^{[1
]}

Miklos, Ferenc ^{[2
]}

Porkolab, Andrea ^{[1
]}

机构：

[1] Taxus Res Lab, Bocskai U 22, H-4080 Hajdunanas, Hungary

[2] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary

来源：

ARKIVOC | 2013年

关键词：

Isoindoles; NSAIDs; cyclooxygenase (COX); enzyme inhibition; Indoprofen analogues; molecular modeling; CYCLOOXYGENASE-2; INHIBITION;

D O I：

10.3998/ark.5550190.0014.225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Searching new targets for anti-inflammatory drug design, agents with the isoindole skeleton were focused on the basis of preliminary studies of NSAIDs as COX-1 and/or COX-2 enzyme inhibitors. Thus several novel N-substituted isoindoline derivatives as possible biologically active compounds were prepared as analogues of Indoprofen (1) starting from cis-2-[(4-methylphenyl)carbonyl]cyclohexanecarboxylic acid (3) by treatment with primary arylamines.

引用

页码：378 / 388

页数：11

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