Transforming growth factor beta is protective in host resistance against Listeria monocytogenes infection in mice

被引：19
|
作者：
Nakane, A
Asano, M
Sasaki, S
Nishikawa, S
Miura, T
Kohanawa, M
Minagawa, T
机构：
[1] HIROSAKI UNIV,SCH ALLIED MED SCI,HIROSAKI,AOMORI 036,JAPAN
[2] HOKKAIDO UNIV,SCH MED,DEPT MICROBIOL,SAPPORO,HOKKAIDO 060,JAPAN
来源：
INFECTION AND IMMUNITY | 1996年 / 64卷 / 09期
关键词：
D O I：
10.1128/IAI.64.9.3901-3904.1996
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of transforming growth factor beta (TGF-beta) in host resistance against Listeria monocytogenes infection was studied with mice. The constitutive expression of TGF-beta 1 mRNA was observed in the spleens and livers of mice before and after infection. Injecting the mice with anti-TGF-beta 1 peptide serum resulted in diminished antilisterial resistance, whereas the administration of human platelet-derived TGF-beta 1 enhanced the resistance. Moreover, mice were protected against lethal infection when treated with TGF-beta 1. These results suggest that TGF-beta 1 might be involved in antilisterial resistance. On the other hand, injecting the mice with TGF-beta 1 resulted in a decrease in the titers of endogenous gamma interferon, tumor necrosis factor alpha, and interleukin-6, which are crucial in antilisterial resistance, in sera and in extracts of spleen and liver. Thus, a complicated mechanism might be involved in the role of TGF-beta 1 in host resistance against L. monocytogenes infection.
引用
收藏
页码：3901 / 3904
页数：4
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