Electrochemotherapy against colorectal carcinoma:: comparison of in vitro cytotoxicity of 5-fluorouracil, cisplatin and bleomycin

被引：0
|
作者：
Kuriyama, S [1 ]
Matsumoto, M [1 ]
Mitoro, A [1 ]
Tsujinoue, H [1 ]
Toyokawa, Y [1 ]
Nakatani, T [1 ]
Yamazaki, M [1 ]
Okamoto, S [1 ]
Fukui, H [1 ]
机构：
[1] Nara Med Univ, Dept Internal Med 3, Kashihara, Nara 6348522, Japan
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1999年 / 15卷 / 01期
关键词：
electrochemotherapy; electroporation; electropermeabilization; colorectal carcinoma; bleomycin; cisplatin; 5-fluorouracil;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Effectiveness of electrochemotherapy against colorectal carcinoma (CRC) was investigated in vitro using murine CRC cell lines. Electropermeabilization did not increase the sensitivity of CRC cells to 5-fluorouracil or cisplatin. Conversely, electropermeabilization markedly increased the sensitivity of CRC cells to bleomycin (BLM), resulting in 1,000-fold higher susceptibility. Subsequent analyses revealed that electropermeabilization significantly increased intracellular BLM levels of CRC cells. These results suggest that electrochemotherapy with BLM is a promising modality for the treatment of CRC, and that electrochemotherapy can be translated from the treatment of superficial tumors to the treatment of internal tumors including CRC.
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页码：89 / 94
页数：6
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