Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation

被引：15
|
作者：
Barr, TA [1 ]
Heath, AW [1 ]
机构：
[1] Univ Sheffield, Sch Med, Div Mol & Genet Med, Sheffield S10 2RX, S Yorkshire, England
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 07期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/IAI.67.7.3637-3640.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.
引用
收藏
页码：3637 / 3640
页数：4
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