Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation

被引：15

作者：

Barr, TA ^{[1
]}

Heath, AW ^{[1
]}

机构：

[1] Univ Sheffield, Sch Med, Div Mol & Genet Med, Sheffield S10 2RX, S Yorkshire, England

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.67.7.3637-3640.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.

引用

页码：3637 / 3640

页数：4

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