Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients

被引：651

作者：

Chia, Po Ying ^{[1
,2
,3
]}

Coleman, Kristen Kelli ^{[4
]}

Tan, Yian Kim ^{[5
]}

Ong, Sean Wei Xiang ^{[1
,2
]}

Gum, Marcus ^{[5
]}

Lau, Sok Kiang ^{[5
]}

Lim, Xiao Fang ^{[5
]}

Lim, Ai Sim ^{[5
]}

Sutjipto, Stephanie ^{[1
,2
]}

Lee, Pei Hua ^{[1
,2
]}

Son, Than The ^{[4
]}

Young, Barnaby Edward ^{[1
,2
,3
]}

Milton, Donald K. ^{[6
]}

Gray, Gregory C. ^{[4
,7
,8
,9
]}

Schuster, Stephan ^{[10
]}

Barkharn, Timothy ^{[2
,11
]}

De, Partha Pratim ^{[2
,3
]}

Vasoo, Shawn ^{[1
,2
,3
]}

Chan, Monica ^{[1
,2
]}

Ang, Brenda Sze Peng ^{[1
,2
,3
,11
]}

Tan, Boon Huan ^{[5
]}

Leo, Yee-Sin ^{[1
,2
,3
,11
]}

Ng, Oon-Tek ^{[1
,2
,3
]}

Wong, Michelle Su Yen ^{[5
]}

Marimuthu, Kalisvar ^{[1
,2
,11
]}

机构：

[1] Natl Ctr Infect Dis, Singapore, Singapore

[2] Tan Tock Seng Hosp, Singapore, Singapore

[3] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

[4] Natl Univ Singapore, Duke NUS Med Sch, Singapore, Singapore

[5] DSO Natl Labs, Singapore, Singapore

[6] Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA

[7] Duke Univ, Sch Med, Durham, NC USA

[8] Duke Univ, Global Hlth Inst, Durham, NC USA

[9] Duke Kunshan Univ, Global Hlth Res Ctr, Kunshan, Peoples R China

[10] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore, Singapore

[11] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

关键词：

D O I：

10.1038/s41467-020-16670-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding the particle size distribution in the air and patterns of environmental contamination of SARS-CoV-2 is essential for infection prevention policies. Here we screen surface and air samples from hospital rooms of COVID-19 patients for SARS-CoV-2 RNA. Environmental sampling is conducted in three airborne infection isolation rooms (AIIRs) in the ICU and 27 AIIRs in the general ward. 245 surface samples are collected. 56.7% of rooms have at least one environmental surface contaminated. High touch surface contamination is shown in ten (66.7%) out of 15 patients in the first week of illness, and three (20%) beyond the first week of illness (p = 0.01, chi(2) test). Air sampling is performed in three of the 27 AIIRs in the general ward, and detects SARS-CoV-2 PCR-positive particles of sizes >4 mu m and 1-4 mu m in two rooms, despite these rooms having 12 air changes per hour. This warrants further study of the airborne transmission potential of SARS-CoV-2.

引用

页数：7

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