The Alzheimer's disease metabolic brain pattern in mild cognitive impairment

被引：28

作者：

Meles, Sanne K. ^{[1
]}

Pagani, Marco ^{[2
,3
]}

Arnaldi, Dario ^{[4
,5
]}

De Carli, Fabrizio ^{[6
]}

Dessi, Barbara ^{[4
,5
]}

Morbelli, Silvia ^{[5
,7
]}

Sambuceti, Gianmario ^{[5
,7
]}

Jonsson, Cathrine ^{[8
]}

Leenders, Klaus L. ^{[1
]}

Nobili, Flavio ^{[4
,5
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

[2] CNR, Inst Cognit Sci & Technol, Rome, Italy

[3] Karolinska Hosp, Dept Nucl Med, Stockholm, Sweden

[4] Univ Genoa, Clin Neurol, Dept Neurosci DINOGMI, Genoa, Italy

[5] IRCCS AOU San Martino IST, Genoa, Italy

[6] AOU San Martino IST, Natl Res Council, Inst Mol Bioimaging & Physiol, Genoa Unit, Genoa, Italy

[7] Univ Genoa, Nucl Med, Dept Hlth Sci DISSAL, Genoa, Italy

[8] Karolinska Univ Hosp, Med Radiat Phys & Nucl Med, Imaging & Physiol, Stockholm, Sweden

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2017年 / 37卷 / 12期

关键词：

F-18-FDG-PET; principal component analysis; normal aging; mild cognitive impairment; Alzheimer's disease; NETWORK ACTIVITY; DIFFERENTIAL-DIAGNOSIS; PARKINSONS-DISEASE; PET DATA; DEMENTIA; VALIDATION; BIOMARKERS; RESERVE;

D O I：

10.1177/0271678X17732508

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in F-18-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of F-18-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.

引用

页码：3643 / 3648

页数：6

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