Longitudinal neuropsychological test performance among HIV seropositive individuals in Uganda

被引:19
|
作者
Sacktor, Ned [1 ,7 ]
Nakasujja, Noeline [2 ]
Okonkwo, Ozioma [1 ,3 ]
Skolasky, Richard L. [4 ]
Robertson, Kevin [5 ]
Musisi, Seggane [2 ]
Katabira, Elly [6 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] Makerere Univ, Dept Psychiat, Kampala, Uganda
[3] Univ Wisconsin, Dept Med, Madison, WI USA
[4] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[5] Univ N Carolina, Dept Neurol, Chapel Hill, NC USA
[6] Makerere Univ, Dept Med, Kampala, Uganda
[7] Johns Hopkins Bayview Med Ctr, Dept Neurol, Baltimore, MD 21224 USA
关键词
HIV; Dementia; Neurocognitive; Neuropsychological assessment; Uganda; DEMENTIA; COMPLICATIONS; RISK;
D O I
10.1007/s13365-012-0139-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study was conducted to evaluate longitudinal neuropsychological testing performance over a 12-month period among HIV + individuals, and to evaluate the impact of antiretroviral therapy (ART) initiation on neuropsychological test changes in Uganda. The study examined 77 HIV + individuals recruited from the Infectious Diseases Clinic at Makerere University, Uganda. They underwent detailed sociodemographic, medical history, immune status, functional, neurologic, and neuropsychological evaluations at baseline and 12 months later. Thirty-one individuals initiated ART (ART group) after their baseline visit, whereas 46 individuals were not placed on ART (no-ART group) during those 12 months. Paired samples t-tests were used to evaluate longitudinal changes in neuropsychological test performance for the entire sample, as well as for groups defined by ART initiation and baseline neurocognitive status. The study evaluated 77 HIV individuals (62 % women, mean age = 37 years, mean education = 8 years, mean CD4 count = 235 cells/mu l). Both the ART and no-ART groups showed significant improvements in tests of verbal memory, executive functioning, motor, and psychomotor speed performance, as well as depression symptoms. The ART group had significant improvements in CD4 count over the 12-month period (p < 0.001), whereas the no-ART group had no CD4 count improvement. ART use is associated with improvements in cognitive functioning among HIV + individuals in Uganda. However, these improvements did not appear to be higher than those seen among HIV + individuals who did not initiate ART. Possible reasons for this include practice effects among the no-ART group as well as improvements in their mood and overall quality of life.
引用
收藏
页码:48 / 56
页数:9
相关论文
共 50 条
  • [31] NEUROPSYCHOLOGICAL ABNORMALITIES IN ASYMPTOMATIC HIV SEROPOSITIVE MILITARY PERSONNEL
    KLUSMAN, LE
    MOULTON, JM
    HORNBOSTEL, LK
    PICANO, JJ
    BEATTIE, MT
    [J]. JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 1991, 3 (04) : 422 - 428
  • [32] Differential Relationships Among Speeded Neuropsychological Test Performance and Facets of Impulsivity in Individuals with Substance Use Disorder
    Mulhauser, K.
    Van Patten, R.
    Merz, Z.
    Farney, M.
    White, T.
    Wenzel, K.
    Weinstock, J.
    [J]. ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2016, 31 (06) : 632 - 632
  • [33] Body Composition Among HIV-Seropositive and HIV-Seronegative Adult Patients with Pulmonary Tuberculosis in Uganda
    Mupere, Ezekiel
    Zalwango, Sarah
    Chiunda, Allan
    Okwera, Alphonse
    Mugerwa, Roy
    Whalen, Christopher
    [J]. ANNALS OF EPIDEMIOLOGY, 2010, 20 (03) : 210 - 216
  • [34] Repeat HIV testing of individuals with discrepant HIV self-test results in Central Uganda
    Rose Kisa
    Joseph K. B. Matovu
    Esther Buregyeya
    William Musoke
    Caroline J. Vrana-Diaz
    Jeffrey E. Korte
    Rhoda K. Wanyenze
    [J]. AIDS Research and Therapy, 16
  • [35] Repeat HIV testing of individuals with discrepant HIV self-test results in Central Uganda
    Kisa, Rose
    Matovu, Joseph K. B.
    Buregyeya, Esther
    Musoke, William
    Vrana-Diaz, Caroline J.
    Korte, Jeffrey E.
    Wanyenze, Rhoda K.
    [J]. AIDS RESEARCH AND THERAPY, 2019, 16 (01)
  • [36] RESULTS OF LONGITUDINAL IMMUNOLOGICAL SURVEILLANCE OF INDIVIDUALS DIRECTLY OR INDIRECTLY INFECTED BY A SINGLE HIV SEROPOSITIVE DONOR
    HOLLAN, SR
    UJHELYI, E
    PALOCZI, K
    SZELENYI, J
    ILLEI, G
    MEDRANO, L
    FUCHS, D
    ISTVAN, L
    SZABO, J
    BANHEGYI, D
    VARNAI, F
    HORVATH, A
    WACHTER, H
    MEDGYESI, GA
    FUST, G
    [J]. TRANSFUSION SCIENCE, 1990, 11 (01): : 73 - 78
  • [37] Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals
    Clifford, DB
    Evans, S
    Yang, YJ
    Acosta, EP
    Goodkin, K
    Tashima, K
    Simpson, D
    Dorfman, D
    Ribaudo, H
    Gulick, RM
    [J]. ANNALS OF INTERNAL MEDICINE, 2005, 143 (10) : 714 - 721
  • [38] Heavy alcohol consumption in individuals with HIV infection: Effects on neuropsychological performance
    Rothlind, JC
    Greenfield, TM
    Bruce, AV
    Meyerhoff, DJ
    Flenniken, DL
    Lindgren, JA
    Weiner, MW
    [J]. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2005, 11 (01) : 70 - 83
  • [39] Liver transplantation in HIV-seropositive individuals
    Ragni, MV
    Belle, SH
    Im, K
    Fung, J
    Neff, G
    Roland, M
    Stock, P
    Heaton, N
    Humar, A
    [J]. ANNALS OF INTERNAL MEDICINE, 2006, 144 (03) : 223 - 223
  • [40] Mycoplasma fermentans in HIV seropositive individuals.
    Chianchitlert, A
    Chingbingyong, MI
    Warner, NA
    Gregory, RL
    Hughes, CV
    [J]. JOURNAL OF DENTAL RESEARCH, 1997, 76 : 3398 - 3398