A BODIPY fluorescent probe with selective response for hypochlorous acid and its application in cell imaging

被引：50
|
作者：
Gai, Lizhi [1 ]
Mack, John [2 ]
Liu, Hui [1 ]
Xu, Zheng [1 ]
Lu, Hua [1 ]
Li, Zhifang [1 ]
机构：
[1] Hangzhou Normal Univ, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 310012, Zhejiang, Peoples R China
[2] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2013年 / 182卷
关键词：
Hypochlorous acid; BODIPY; TD-DFT; Fluorescent probe; Cell image; INTRAMOLECULAR CHARGE-TRANSFER; TURN-ON; ELECTRON-TRANSFER; SYNOVIAL-FLUID; DYES; ATHEROSCLEROSIS; OXIDATION; STATE; RED;
D O I：
10.1016/j.snb.2013.02.106
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A boron-dipyrromethene (BODIPY) derivative with a hydroxymethyl group at the mesa-position, 1, was synthesized, which exhibits a highly specific and rapid 'turn-off' response for HOCl during confocal fluorescence microscopy experiments under physiological conditions and in live cells. The formation of an electron-withdrawing formyl substituent upon oxidation results in highly efficient nonradiative decay of the S-1 state and hence in a drastic decrease in fluorescence emission intensity. (C) 2013 Elsevier B.V. All rights reserved.
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页码：1 / 6
页数：6
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