Genome scan for blood pressure loci in mice

被引：47
|
作者：
Wright, FA
O'Connor, DT
Robert, E
Kutey, G
Berry, CC
Yoneda, LU
Timberlake, D
Schlager, G
机构：
[1] Ohio State Univ, Div Human Canc Genet, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[3] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
[4] Univ Calif San Diego, Ctr Mol Genet, San Diego, CA 92103 USA
[5] VA Healthcare Syst, San Diego, CA USA
[6] Univ Calif San Diego, Howard Hughes Med Inst, Div Cellular & Mol Med, La Jolla, CA 92093 USA
[7] Univ Kansas, Genet Program, Lawrence, KS 66045 USA
[8] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA
来源：
HYPERTENSION | 1999年 / 34卷 / 04期
关键词：
linkage; hypertension; genetic; mice; genes;
D O I：
10.1161/01.HYP.34.4.625
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Hypertension is a complex trait of unknown cause in humans, Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1, An F2 intercross Of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant:linkage was observed in the F2s on chromosome 10 (logarithm of the odds score [LOD]=4.9) and on chromosome 13 in the M spretus backcross (LOD=3.3), with additional: suggestive LODs on chromosomes 2, 6, 8, and 18. In addition,several suggestive linkages were observed for phenotypes associated with human hypertension, Our study is the first reported genome-wide linkage scan for blood pressure-genes in the mouse.
引用
收藏
页码：625 / 630
页数：6
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