Wound Healing Effect of Curcumin Gel for Transdermal Delivery

被引：4

作者：

Kim, Jin ^{[1
]}

Kim, Man Jong ^{[1
]}

Lee, C-Young ^{[2
,3
]}

机构：

[1] Chonnam Natl Univ, Dept Adv Chem & Engn, Kwangju 500757, South Korea

[2] Chonnam Natl Univ, Fac Appl Chem Engn, Kwangju 500757, South Korea

[3] Chonnam Natl Univ, Res Inst Catalysis, Kwangju 500757, South Korea

来源：

POLYMER-KOREA | 2013年 / 37卷 / 03期

关键词：

curcumin; cosmeceuticals; transdermal delivery; re-epithelialization; EXPRESSION; PROPOLIS;

D O I：

10.7317/pk.2013.37.3.387

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The aim of this study was to investigate the effect of trasdermal delivery of the curcumin gel on healing of the rats' dorsum wounds. Carbopol 934 and propylene glycol were used to prepare gels containing 1% curcumin. Curcumin gel was evaluated for various properties such as antioxidant, cell viability, anti-inflammatory, in vivo wound healing. The free radical scavenging activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) was 50% at 12.5 ppm concentration. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by curcumin gel. In the curcumin gel-treated group, the re-epithelialization in wounds was significantly increased compared to the control group throughout the experimental period. These results suggested that curcumin may be helpful for the promotion of wound healing.

引用

页码：387 / 392

页数：6

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