A Role for Angiopoietin-2 in Organ-Specific Metastasis

被引：20
|
作者：
Rigamonti, Nicolo [1 ]
De Palma, Michele [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, Swiss Fed Inst Technol Lausanne, CH-1015 Lausanne, Switzerland
来源：
CELL REPORTS | 2013年 / 4卷 / 04期
关键词：
ENDOTHELIAL-CELLS; TUMOR-GROWTH; ANGIOGENESIS;
D O I：
10.1016/j.celrep.2013.07.034
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Angiopoietin-2 (ANG2/ANGPT2) has recently emerged as a promising target for the inhibition of tumor metastasis. In this issue of Cell Reports, Minami et al. show that the calcineurin-NFAT pathway promotes pulmonary tumor metastasis by inducing ANG2 in the lung endothelium.
引用
收藏
页码：621 / 623
页数：3
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