Enantioselective and α-Regioselective Allylic Amination of Morita-Baylis-Hillman Acetates with Simple Aromatic Amines Catalyzed by Planarly Chiral Ligand/Palladium Catalyst

被引：10
|
作者：
Wang Yan [1 ,2 ]
Zhang Tao [1 ,2 ]
Liu Li [1 ]
Wang Dong [1 ]
Chen Yongjun [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 11期
基金：
中国国家自然科学基金;
关键词：
asymmetric allylic amination; Morita-Baylis-Hillman adducts; aromatic amines; palladium catalysis; diphosphine ligands; SUBSTITUTION; DERIVATIVES; CARBONATES; ADDUCTS; HYDROGENATION; DYKAT;
D O I：
10.1002/cjoc.201200771
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An asymmetric allylic amination of Morita-Baylis-Hillman acetates with simple aromatic amines catalyzed by planarly chiral ligand/palladium-catalyst was developed in good yield with excellent alpha-regioselectivity (alpha/gamma up to 30 : 1) and moderate enantioselectivity (up to 70% ee).
引用
收藏
页码：2641 / 2646
页数：6
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