Spectrophotometric studies of Diazepam β-cyclodextrin complex formation

被引：0
|
作者：
Kacso, Irina [1 ]
Bratu, Ioan [1 ]
Farcas, Andreea [2 ]
Bojita, Marius [2 ]
机构：
[1] Natl Inst R&D Isotop & Mol Technol, RO-400293 Cluj Napoca, Romania
[2] Univ Med & Pharm Iuliu Hatieganu, Cluj Napoca, Romania
来源：
STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2007年 / 52卷 / 04期
关键词：
FTIR; UV-Vis; stoichiometry; association constant; inclusion compound; beta-cyclodextrin;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Solid state interactions between a bioactive substance-Diazepam and beta-cyclodextrin (beta-CD) - the so called inclusion compounds ( obtained by different preparation methods: kneading, co-precipitation and freeze-drying) were investigated. The obtained compounds were investigated by FTIR spectroscopy to evidence their formation. The results revealed that the solid state inclusion compound, such as Diazepam/beta-cyclodextrin has a good stability. The stoichiometry of the inclusion complexes of diazepam with beta-CD is 1:1 was investigated in solution. The association constant of the complex was determined by UV spectrophotometry. The encapsulation might improve Diazepam stability and bioavailability of the drug.
引用
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页码：131 / 136
页数：6
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