Pd-Catalyzed Alkyne Insertion/C-H Activation/[4+2] Carboannulation of Alkenes to the Synthesis of Polycyclics

被引：12

作者：

Guo, Songjin ^{[1
,2
]}

Li, Panpan ^{[1
,2
]}

Guan, Zhe ^{[1
,2
]}

Cai, Libo ^{[1
,2
]}

Chen, Siwei ^{[1
,2
]}

Lin, Aijun ^{[1
,2
]}

Yao, Hequan ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 04期

基金：

中国国家自然科学基金;

关键词：

INTERNAL ALKYNES; ARYL IODIDES; CYCLOCARBOPALLADATION; FUNCTIONALIZATION; CYCLIZATION; REACTIVITY; PATHWAYS;

D O I：

10.1021/acs.orglett.8b03884

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented Pd-catalyzed alkyne insertion/C-H activation/intramolecular [4 + 2] carboannulation of alkenes has been reported. In this transformation, the C-H activation was triggered by an in situ generated alkenylpalladium species via the Pd-catalyzed cross-coupling reaction of aryl iodides and alkynes. Subsequently, the resulting five-membered C, C-palladacyde intermediates were added across the alkenes, providing a unique approach to access diversified polycyclics in good efficiency. Two new rings and three C-C bonds were formed in one pot.

引用

页码：921 / 925

页数：5

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