Background: Previous studies have shown that cytokine mRNA expression is elevated in the brains of anorectic, tumor-bearing rats. The objectives of the current study were as follows: (1) to determine whether a small tumor would result in up-regulation of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta mRNA expression in the brain and other tissues of tumor-bearing mice; and (2) to determine whether hyperalimentation by tube feeding would prevent up-regulation of cytokine mRNA expression in the brain and other tissues of tumor-bearing mice. Methods: Male C57BL/6 mice were divided into 4 groups: (1) control mice fed ad libitum (Control); (2) tumor-bearing mice fed ad libitum (TB); (3) control mice receiving tube feeding (CTF); and (4) tumor-bearing mice receiving tube feeding (TBTF). Results: TNF-alpha and IL-1 beta mRNA expression was elevated in the brains of mice with a 1% body weight tumor, relative to the control and CTF groups, without any detectable changes in the other organs. On the other hand, TNF-alpha and IL-1 beta mRNA expression was elevated in all organs of mice with an 8% body weight tumor, relative to the control and CTF groups. Tube feeding did not change TNF-alpha and IL-1 beta mRNA expression in mice burdened with either a 1% or 8% body weight tumor. Conclusions: Up-regulation of cytokine mRNA synthesis occurs earlier in the brain than in other organs, and hyperalimentation does not change cytokine mRNA expression in tumor-bearing mice.
机构:
Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USAWashington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
Krueger, JM
Fang, JD
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Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USAWashington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
Fang, JD
Ping, TS
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Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USAWashington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
Ping, TS
Chen, ZT
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Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USAWashington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
Chen, ZT
Kushikata, T
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Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USAWashington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
Kushikata, T
Gardi, J
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Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USAWashington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
Gardi, J
MOLECULAR MECHANISMS OF FEVER,
1998,
856
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159
机构:
King Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Khan, Haseeb A.
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Ibrahim, Khalid E.
Alrashood, Sara T.
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King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Alrashood, Sara T.
Alamery, Salman
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King Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
King Saud Univ, Coll Sci, Ctr Excellence Biotechnol Res, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Alamery, Salman
Alrokayan, Salman H.
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King Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Alrokayan, Salman H.
Al-Harbi, Najla
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King Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Al-Harbi, Najla
Al-Mutary, Mohsen G.
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Imam Abdulrahman Bin Faisal Univ, Coll Educ, Dept Basic Sci, Dammam 34212, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Al-Mutary, Mohsen G.
Sobki, Samia H.
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Prince Sultan Mil Med City, Dept Cent Mil Lab & Blood Bank, Riyadh 11159, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
Sobki, Samia H.
Khan, Isra
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Rohilkhand Med Coll & Hosp, Bareilly 243006, Uttar Pradesh, IndiaKing Saud Univ, Coll Sci, Dept Biochem, Bldg 5,POB 2455, Riyadh 11451, Saudi Arabia
机构:
Univ Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, ItalyUniv Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, Italy
Sabbadini, M
Barisani, D
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Univ Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, ItalyUniv Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, Italy
Barisani, D
Conforti, E
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Univ Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, ItalyUniv Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, Italy
Conforti, E
Miserocchi, G
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Univ Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, ItalyUniv Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, Italy
Miserocchi, G
Meneveri, R
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Univ Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, ItalyUniv Milan, Dipartimento Med Sperimentale Amb & Biotecn Med, I-20052 Milan, Italy
机构:
Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Univ Illinois, Coll Med, Urbana, IL 61801 USAUniv Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Moon, Morgan
Joesting, Jennifer
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Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USAUniv Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Joesting, Jennifer
Freund, Gregory
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Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA
Univ Illinois, Coll Med, Urbana, IL 61801 USA
Univ Illinois, Anim Sci, Urbana, IL 61801 USAUniv Illinois, Div Nutr Sci, Urbana, IL 61801 USA