Animal Models for Dysphagia Studies: What Have We Learnt So Far

被引:48
|
作者
German, Rebecca Z. [1 ]
Crompton, A. W. [2 ]
Gould, Francois D. H. [1 ]
Thexton, Allan J. [3 ]
机构
[1] Northeast Ohio Med Univ, Dept Anat & Neurosci, Rootstown, OH 44272 USA
[2] Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA
[3] Kings Coll London, Div Physiol, Guys Campus, London SE1 9RT, England
关键词
Animal models; Performance; Pathophysiology; Deglutition; Deglutition disorders; SUPERIOR LARYNGEAL NERVE; WIRE INTRAMUSCULAR ELECTRODES; RAT MODEL; ELECTRICAL-STIMULATION; SWALLOWING REFLEX; SILENT ASPIRATION; TONGUE FORCE; ELECTROMYOGRAPHY; INFANT; LESION;
D O I
10.1007/s00455-016-9778-7
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in and day out care about this work? Results from studies of animal models have the potential to change and grow how we think about dysphagia research and practice in general, well beyond applying specific results to human studies. Animal research provides two key contributions to our understanding of dysphagia. The first is a more complete characterization of the physiology of both normal and pathological swallow than is possible in human subjects. The second is suggesting of specific, physiological, targets for development and testing of treatment interventions to improve dysphagia outcomes.
引用
收藏
页码:73 / 77
页数:5
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