Peptides from Mamba Venom as Pain Killers

被引：7
|
作者：
Craik, David J. [1 ]
Schroeder, Christina I. [1 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 11期
关键词：
ion channels; pain; peptides; toxins; venoms; SENSING ION CHANNELS; TARGET;
D O I：
10.1002/anie.201209851
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The black mamba snake here illustrates the structure of mambaglin-1, a pain-relieving peptide found in its venom. Thick gray lines lines represent the four disulfide bonds linking Cys1-3, 2-4, 5-6, and 7-8. The N-terminus of the 57 amino acid peptide is at the head of the snake and the C-terminus at the tail. The peptide has potential as a pharmacological probe or drug lead. Image design by David Craik and drawing by Peta Harvey, University of Queensland. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3071 / 3073
页数：3
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