Design of an "Active Defense" System as Drug Carriers for Cancer Therapy

被引：39
|
作者：
Zhang, Jing [1 ,2 ]
Xu, Xiao-Ding [1 ,2 ]
Liu, Yun [1 ,2 ]
Liu, Chen-Wei [1 ,2 ]
Chen, Xiu-Hong [1 ,2 ]
Li, Cao [1 ,2 ]
Zhuo, Ren-Xi [1 ,2 ]
Zhang, Xian-Zheng [1 ,2 ]
机构：
[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
来源：
ADVANCED FUNCTIONAL MATERIALS | 2012年 / 22卷 / 08期
基金：
中国国家自然科学基金;
关键词：
active defense; microcapsule; exploding; drug delivery; NANOPARTICLES; RELEASE; MICELLES; DELIVERY;
D O I：
10.1002/adfm.201102132
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel intelligent active defense system that can specially respond to cancerous tissues for drug release was designed and prepared. The active defense system consists of a biodegradable dextran microgel core cross-linked by a Schiff's base and a surrounding layer formed by Layer-by-Layer (LbL) assembly. The loading and release of macromolecular model drug, dex-FITC, as well as antineoplastic drug, DOX, was investigated. The in vitro cell inhibition and drug release behavior of the drug delivery system were studied and the results showed that the entrapped drug could be explosively released from the microcapsules and thereafter taken up by cancer cells upon the trigger of the acidic environment around tumor tissues.
引用
收藏
页码：1704 / 1710
页数：7
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