SYNTHESIS, MOLECULAR CONFORMATION AND ACTIVITY AGAINST HERPES SIMPLEX VIRUS OF (E)-5-(2-BROMOVINYL)-2′-DEOXYCYTIDINE ANALOGS

被引：0

作者：

Zoghaib, Wajdi Michel ^{[1
]}

Mannala, Shajan ^{[3
]}

Gupta, V. Sagar ^{[3
]}

Tourigny, Guy ^{[2
]}

机构：

[1] Sultan Qaboos Univ, Dept Chem, Al Khoud 123, Oman

[2] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 0W0, Canada

[3] Univ Saskatchewan, Dept Biomed Sci, Saskatoon, SK S7N 0W0, Canada

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2012年 / 31卷 / 04期

基金：

英国医学研究理事会;

关键词：

Herpes simplex virus; (E)-5-(2-bromovinyl)-2 '-deoxycytidine; conformational analysis; CRYSTAL-STRUCTURES; THYMIDINE KINASE; 5-METHOXYMETHYL-2'-DEOXYCYTIDINE; NUCLEOSIDES; DNA;

D O I：

10.1080/15257770.2012.661214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogs of (E)-5-(2-bromovinyl)-2'-deoxycytidine (BrVdCyd) (1) by substitution at N-4 were synthesized to impart resistance against deamination. The anti-HSV-1 activity and solution conformation of these analogs were determined. N-4-Acetyl-BrVdCyd (2) was a potent inhibitor of HSV-1 replication whereas N-4-propanoyl-BrVdCyd (3) had good activity and N-4-Butanoyl-BrVdCyd (4) had only low activity against HSV-1 replication. N-4-Methyl-BrVdCyd (5) was devoid of activity against HSV-1.

引用

页码：364 / 376

页数：13

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